ZUVIPLAT is an anticancer drug of an entirely new category for antitumor activity and low toxicity from among a variety platinum compound developed according to the discovery by Barnett Rosenberg in the U.S.A that platinum compound inhibit the mitosis of Escherichia coli.<\/p>\n
![\"Zuviplat\"](\"https:\/\/i0.wp.com\/www.zuviuslifesciences.in\/media\/34473\/zuviplat.jpg?ssl=1\")
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[\/vc_column_text][\/vc_tta_section][vc_tta_section title=”Composition” tab_id=”1593252117995-465afa63-4c38″][vc_column_text]ZUVIPLAT – Aqueous Injection\u00a0is sterile aqueous solution containing 1mg of Cisplatin I.P. in each ml.[\/vc_column_text][\/vc_tta_section][vc_tta_section title=”Mechanism of Action” tab_id=”1584624217032-a15849ed-97bb”][vc_column_text]CLINICAL PHARMACOLOGY<\/strong> Following single: i.v dose ZUVIPLAT concentrates in the liver, kidney and large and small intestine in animals and human. ZUVIPLAT apparently has poor penetration into the central nervous system. The half in the \u03b2 phase is 58-73 hours. About 90% of the drugs bound to protein and this binding is only partly reversible. Urinary excretion of ZUVIPLAT range between 27-45% of the administered dose within the first 5 days the rest presumable is fixed in tissue and metabolized<\/p>\n<\/div>\n<\/div>\n<\/div>\n [\/vc_column_text][\/vc_tta_section][vc_tta_section title=”Indications” tab_id=”1584624459062-96fb7e5b-0e23″][vc_column_text]<\/p>\n ZUVIPLAT can be used itself or in addition to other modalities or preferable in established combination therapy with other approved chemotherapeutic agent. It is indicated in metastic ovarian turnovers, squamous cell carcinoma of the head and neck and advance bladder carcinoma.<\/p>\n [\/vc_column_text][\/vc_tta_section][vc_tta_section title=”Dosage & Administration” tab_id=”1584624839401-59481bbb-bdc7″][vc_column_text]<\/p>\n ZUVIPLAT solution should be used intravenously only and should be administered by i.v dose every 3-4 week. An alternative regimen is 15-20 mg per sq. i.v daily for 5 days every 3-4 week In clinical use of ZUVIPLAT injection, take the following measure for reducing the nephrotoxicity of the drug: Administer 1000-2000 ml. of an adequate fluid deficit replacement over 4 hours or more prior to the administration of ZUVIPLAT injection. Administer ZUVIPLAT injection as a mixture with 500-1000 ml of physiological saline or a dextrose \u2013saline solution by intravenous drip over 2 hours or more. When it take the intravenous drip over 2 hours or more. When it take the intravenous drip of ZUVIPLAT injection a long time, keep the dripping bottle away from light. After the administration of ZUVIPLAT injection, administer 1000-2000 ml of an adequate fluid deficit replacement over 4 hours or more. During the administration of ZUVIPLAT injection, exercise care so as to maintain the urinary output and administer diuretic such as mannitol and furosemide.<\/p>\n<\/div>\n<\/div>\n<\/div>\n [\/vc_column_text][\/vc_tta_section][vc_tta_section title=”Warnings” tab_id=”1584625017135-3ffdd9c5-1bd6″][vc_column_text]Because gastrointestinal symptoms such as nausea, vomiting and anorexia are complained of the all treated patients , keep under close observation for change is condition and take adequate measure when such complaint have appeared.<\/p>\n Because the treatment with ZUVIPLAT injection may in some cases be associated with severe adverse reaction such as renal failure and myelosuppression , keep the patients under close observation for change in condition e.g by frequent Laboratory examination ( such as renal function test, hematology and hepatic function test) When an abnormality has been found take adequate measure such as reduction in the dose of ZUVIPLAT injection may in some cases be associated with severe, persistent adverse reaction, exercise particular care in such a case<\/p>\n Exercise care specially on the onset or aggravation of infection and hemorrhagic tendency under the treatment with ZUVIPLAT injection<\/p>\n When ZUVIPLAT injection is administered to children, exercise particular care on the onset of adverse reaction, and administer the drug with the utmost care. (There is a report from another country that ototoxicity is a frequent adverse reaction to ZUVIPLAT).<\/p>\n When it is necessary to administer ZUVIPLAT injection to children and patients at the reproductive age. Its effect on the genital organs need to be consider.<\/p>\n [\/vc_column_text][\/vc_tta_section][vc_tta_section title=”Precautions” tab_id=”1587813742058-49e5505b-66f3″][vc_column_text]PRECAUTION SPECIAL:<\/strong><\/p>\n Patients with renal disorder<\/p>\n Patients with hepatic disorder<\/p>\n Patients with myelosuppression<\/p>\n Patients with auditory disorder.<\/p>\n ZUVIPLAT solution should be drawn up out of the vial using a syringe and sterile technique and added to 2 liters of either a 5% dextrose in1\/3 normal saline solution, or 5% dextrose in a normal saline solution. 37.5 gm of mannitol should also be added in the infusion solution. As with other potentially toxic compounds. Caution in handling the solution of ZUVIPLAT should be exercised. Skin reactor associated with accidental exposure to ZUVIPLAT may occur. The use of the gloves is recommended. If ZUVIPLAT solution comes in the contract with skin or mucosa, immediately wash thoroughly with soap and water. Do not mix ZUVIPLAT injection with 5% dextrose, amino acid solution or any solution containing sodium locate for administration for intravenous drip, because ZUVIPLAT may be degraded in such a mixture. Because ZUVIPLAT react with aluminumto form precipitate, resulting in deteriorated activity Because ZUVIPLAT is a chelate compound, ZUVIPLAT injection should not be mixed with any other anticancer drugs ZUVIPLAT injection when mixed with physiological saline or a dextrose- saline solution, should be administered as early as possible Because ZUVIPLAT is degraded by light keep ZUVIPLAT injection away from direct sunlight When it take the intravenous drip of PLATINEX injection a long time keep the dripping bottle away from light<\/p>\n OTHER PRECAUTION:<\/strong><\/p>\n It has been report that the administration of ZUVIPLAT injection may in some cases be associated with congestive heart failures and abnormal ECG, and also with hypomagnesaemia and hypocalcemia 3<\/p>\n ZUVIPLAT has proved mutagenic in bacteria<\/p>\n Its has been reported that the intra peritoneal administration of ZUVIPLAT to mice caused pulmonary adenoma and skin turnover<\/p>\n USE IN PREGNANCY:<\/strong><\/p>\n ZUVIPLAT is carcinogenic ans should be considered teratogenic. Termination of pregnancy (especially first trimester) should be considered in patients given ZUVIPLAT<\/p>\n<\/div>\n<\/div>\n [\/vc_column_text][\/vc_tta_section][vc_tta_section title=”Adverse Reactions (Side Effects)” tab_id=”1587813861245-10d730f5-694b”][vc_column_text]Gastrointestinal tract:<\/strong>\u00a0Nausea, vomiting, anorexia, may be complained of by almost al m patients: and other gastrointestinal symptoms such as diarrhea and abdominal pain also may occasionally be complained of.<\/p>\n Kidney:<\/strong>\u00a0Because the treatment with ZUVIPLAT injection may in some cases be associated with renal failure keep the patients under close observation for such a change. When any abnormality has occurred in laboratory parameters such as BUN, serum creatinine and creatinine clearances value, withdraw the treatment and take adequate measure. And when any other abnormalities such as hematuria and urinary protein also have occurred withdraw the treatment and take adequate measure<\/p>\n Blood:<\/strong>\u00a0Leucopenia, throbopenia and anemia may appear on rare occasions.<\/p>\n Auditory Organ:<\/strong>\u00a0Hearing loss of the high frequency range and tinnitus may appear in some cases<\/p>\n Hypersensitivity:<\/strong>\u00a0Symptoms and sign of hypersensitivity such as rashes may appear occasionally<\/p>\n Nervous System:<\/strong>\u00a0Symptoms of the peripheral nervous system such as numbness and paresthesia of the finger and toes may appear on rate occasion<\/p>\n Liver:<\/strong>\u00a0Abnormal hepatic function test such as elevation of S-GOT, S-GPT and A1- P may sometime be observed<\/p>\n Other changes:<\/strong>\u00a0Generalized malaise dizziness, alopecia, fever, general edema, hypotension and hiccups may occur in some cases.[\/vc_column_text][\/vc_tta_section][vc_tta_section title=”Drug Interactions” tab_id=”1587813956094-3b0f9c68-b5b7″][vc_column_text]<\/p>\n Plasma levels of anticonvulsant agents may become sub therapeutic during cisplatin (cisplatin injection) therapy. In a randomized trial in advanced ovarian cancer, response duration was adversely affected when pyridoxine was used in combination with altretamine (hexamethylmelamine) and cisplatin (cisplatin injection) .<\/p>\n [\/vc_column_text][\/vc_tta_section][vc_tta_section title=”Overdose & Contradiction” tab_id=”1587814013713-60df48a2-b94f”][vc_column_text]<\/p>\n Caution should be exercised to prevent inadvertent overdosage with cisplatin (cisplatin injection)\u00a0Acute\u00a0overdosage with this drug may result in\u00a0kidney\u00a0failure,\u00a0liver\u00a0failure,\u00a0deafness,\u00a0ocular\u00a0toxicity\u00a0(including detachment of the\u00a0retina), significant myelosuppression, intractable\u00a0nausea\u00a0and vomiting and\/or\u00a0neuritis. In addition, death can occur following overdosage.<\/p>\n No proven antidotes have been established for cisplatin (cisplatin injection) overdosage.\u00a0Hemodialysis, even when initiated four hours after the overdosage, appears to have little effect on removing platinum from the body because of cisplatin (cisplatin injection) ‘s rapid and high degree of\u00a0proteinbinding. Management of overdosage should include general supportive measures to sustain the patient through any period of toxicity that may occur.<\/p>\n CONTRAINDICATIONS:<\/p>\n Patients with severe renal disorder.<\/p>\n Patients with a previous history of severe hypersensitivity to ZUVIPLAT injection<\/p>\n<\/div>\n<\/div>\n<\/div>\n [\/vc_column_text][\/vc_tta_section][vc_tta_section title=”Storage” tab_id=”1587814223983-39ca41e8-f2fb”][vc_column_text]<\/p>\n Store between 15\u1d3cC to 25\u1d3cC. Do not freeze. Protect from light<\/p>\n CAUTION TO BE TAKEN IN HANDLING:<\/strong><\/p>\n Use ZUVIPLAT injection by the direction or according to the prescription of physician.<\/p>\n When ZUVIPLAT injection is mixed with a fluid deficit replacement, the mixture should be used as early as possible<\/p>\n Keep the vial in the vial carton even after its outer package has been opened.<\/p>\n EXPIRY:<\/strong><\/p>\n The date of expiry is indicated on the outer package<\/p>\n<\/div>\n<\/div>\n<\/div>\n [\/vc_column_text][\/vc_tta_section][vc_tta_section title=”Presentation” tab_id=”1587814457828-6b65c45e-5444″][vc_column_text]ZUVIPLAT is available in amber coloured vials containing 1mg\/ml. in packs of 10 ml and 50ml vials.[\/vc_column_text][\/vc_tta_section][\/vc_tta_tour][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":" ZUVIPLAT can be used itself or in addition to other modalities or preferable in established combination therapy with other approved chemotherapeutic agents. It is indicated in metastatic ovarian turnovers, squamous cell carcinoma of the head and neck, and advanced bladder carcinoma.<\/p>\n","protected":false},"featured_media":7850,"template":"","meta":{"spay_email":""},"product_cat":[66,67],"product_tag":[175,173,174],"jetpack-related-posts":[{"id":6717,"url":"https:\/\/zuviuslifesciences.in\/old\/product\/zolon-inj\/","url_meta":{"origin":6673,"position":0},"title":"Zolon Inj","date":"April 27, 2020","format":false,"excerpt":"Oxaliplatin Inj - 150MG 100MG 50MG Oxaliplatin is indicated in the treatment of metastatic colorectal cancers after the failure of treatment of fluoropyrimidines, alone by monochemotherapy or along with fluoropyrimidines. \u00a0","rel":"","context":"Similar 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\nMODE OF ACTION:<\/strong>\u00a0It is accepted that the antitumor activity of ZUVIPLAT derives from its binding to DNA.[\/vc_column_text][\/vc_tta_section][vc_tta_section title=”Pharmacokinetics” tab_id=”1584624217050-ebb8ae5e-43a6″][vc_column_text]<\/p>\nCisplatin\u00a0 Inj- 10MG, 50MG<\/h3>\n