Each tablet (per serving) contains                                        %RDV

Calcium Citrate Malate………………..1180 mg

(equivalent to elemental Calcium)……283.2 mg                  47.2%

Magnesium Sulphate…………………..100 mg                      5.9%

Zinc Sulphate……………………………4 mg                        13.4%

Vitamin D3 (veg source)………………..400 i.u.                    100%

Excipients………………………………..q.s

Calcium-Zinc-Magnesium offers a host of benefits.

• May support bone health

Over 99 % of total body calcium is found in teeth and bones. Our body is constantly regenerating its bone tissue, so it’s important to consume an adequate amount of this mineral daily.
Zinc also helps comprise the mineral portion of your bones. In addition, it supports bone-building cells while inhibiting the formation of cells that encourage bone breakdown.
Finally, magnesium plays a key role in converting vitamin D into its active form, which aids calcium absorption.

• May elevate your mood

Magnesium and zinc are fundamental to brain signals and processes.

• May strengthen immunity

Magnesium and zinc help boost the immune system and reduce inflammation. Supplementing with magnesium has been shown to reduce markers of chronic inflammation, such as C-reactive protein (CRP) and interleukin 6 (IL-6). Zinc plays an important role in the development and function of many immune cells. Supplementing with this mineral may help combat infections and aid wound healing.

• May help control blood sugar levels

Magnesium and zinc may also regulate blood sugar levels. Moreover, research suggests that magnesium may aid to improve utilizing insulin by the body in diabetics.

• May improve sleep quality

Both magnesium and zinc may improve sleep quality. Studies show that magnesium helps stimulate the body’s parasympathetic nervous system, which helps feel calm and relaxed.

Absorbability:

The body must be able to absorb the calcium for it to be effective. All varieties of calcium supplements are better absorbed when taken in small doses (500 mg or less) at mealtimes. Calcium citrate is absorbed equally well when taken with or without food and is a form recommended for individuals with low stomach acid (more common in people over 50 or taking antacids or acid blockers), inflammatory bowel disease, or absorption disorders.
A study was conducted to compare pharmacokinetic indices of calcium absorption after a single oral (500 mg calcium) load of calcium citrate and calcium carbonate. The study demonstrated that Calcium Citrate is much more bioavailable than Calcium Carbonate. In 18 postmenopausal normal women, venous blood samples were obtained for the measurement of calcium before and hourly for 6 hours after oral ingestion of Calcium Citrate, Calcium Carbonate, or placebo with a breakfast meal. The change in area under the curve (delta AUC) in serum calcium from preload was 2.5-fold greater for Citrate Citrate than Calcium Carbonate, and the peak-basal variation in serum calcium was 76% higher for Calcium Citrate than Calcium Carbonate.

• This combination is useful to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets.
• It may be used to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia / rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany).
• It may also be used in certain patients to make sure they are getting enough calcium (including pregnant women, lactating mothers, and postmenopausal women
• Also useful in people taking certain medications such as phenytoin, phenobarbital or prednisone).

Calciboon ZM is to be taken orally with or without food. Tablets should not be chewed or crushed. It should be swallowed with water or milk. It’s better if the dose is taken at a fixed time each day.
The following doses have been studied in scientific research:

BY MOUTH (Oral):

• For preventing low calcium levels: 1-2 grams elemental calcium daily is typically used. Sometimes it is taken with 800 IU of vitamin D.
• For preventing weak bones (osteoporosis) caused by corticosteroid use: Divided daily doses of 0.5-1 gram of elemental calcium daily.
• For prevention of weak bones (osteoporosis): Most experts recommend taking 1000-1200 mg of calcium daily to prevent osteoporosis and broken bones.
• For increasing fetal bone density in pregnant women with low dietary calcium intake: 300-2000 mg/day, taken during the second and third trimesters.
• For high cholesterol: 800 mg daily for up to 2 years. Calcium 1200 mg taken in 2-3 divided doses daily, alone or in combination with vitamin D 400 IU daily, has also been used in conjunction with a low-fat or calorie-restricted diet for up to 15 weeks.
• For preventing high blood pressure during pregnancy (pre-eclampsia): 1-2 grams elemental calcium daily as calcium carbonate.
• For high blood pressure: Up to 0.4-2 grams daily for up to 4 years
• For preventing tooth loss in elderly people: 500 mg of calcium along with 700 IU of vitamin D daily for 3 years.
• For weight loss: Calcium 800-1200 mg daily with or without a calorie-restricted diet has been used. In some cases, calcium is taken in combination with 400 IU of vitamin D.

• Before taking calcium supplement, tell your doctor or pharmacist if you have any allergies.
• This product should not be used if you have certain medical conditions. Before using this product, consult your doctor or pharmacist if you have: high calcium levels (hypercalcemia).
• If you have any of the following health problems, consult your doctor or pharmacist before using this product: kidney disease, kidney stones , little or no stomach acid (achlorhydria), heart disease, disease of the pancreas, a certain lung disease (sarcoidosis), difficulty absorbing nutrition from food (malabsorption syndrome).

USE IN PREGNANCY AND LACTATION 

Calcium needs vary by age—even during pregnancy. The American College of Obstetricians and Gynaecologists (ACOG) recommends that pregnant and breastfeeding moms aged 19 and over-consume 1,000mg of calcium each day.

Though generally safe, calcium, magnesium, and zinc are linked to various side effects on moderate to high doses.

Constipation or stomach upset may occur. Although unlikely to happen, but serious side effects may occur such as nausea/vomiting, loss of appetite, unusual weight loss, mental/mood changes, signs of kidney problems (such as a change in the amount of urine), bone/ muscle pain, headache, increased thirst, increased urination, weakness, tiredness, fast/pounding heartbeat.

A serious allergic reaction to this product is rare. However, serious reactions such as rash, itching/ swelling (especially of the face/ tongue /throat), severe dizziness, trouble breaching may occur and should be reported to the physician immediately.

Major interactions: Following combinations should be not be used.

• Intravenous Ceftriaxone interacts with CALCIUM

Administering intravenous ceftriaxone and calcium can result in life-threatening damage to the lungs and kidneys. Calcium should not be administered intravenously within 48 hours of intravenous ceftriaxone.

Moderate Interaction: Following combinations should be used with caution.

• Antibiotics (Quinolone antibiotics) interacts with CALCIUM

Calcium might decrease how much antibiotic your body absorbs. Taking calcium along with some antibiotics might decrease the effectiveness of some antibiotics. To avoid this interaction, take calcium supplements at least 1 hour after antibiotics. Some of the antibiotics that might interact with calcium include ciprofloxacin, enoxacin, norfloxacin, sparfloxacin, and trovafloxacin.

• Antibiotics (Tetracycline antibiotics) interacts with CALCIUM

Calcium can attach to some antibiotics called tetracyclines in the stomach. This decreases the amount of tetracyclines that can be absorbed. Taking calcium with tetracyclines might decrease the effectiveness of tetracyclines. To avoid this interaction take calcium 2 hours before or 4 hours after taking tetracyclines. Some tetracyclines include demeclocycline, minocycline, and tetracycline (Achromycin, and others).

• Bisphosphonates interacts with CALCIUM

Calcium can decrease how much bisphosphate your body absorbs. Taking calcium along with bisphosphates can decrease the effectiveness of bisphosphate. To avoid this interaction, take bisphosphonate at least 30 minutes before calcium or later in the day. Some bisphosphonates include alendronate, etidronate, risedronate, tiludronate and others.

• Calcipotriene interacts with CALCIUM

Calcipotriene is a drug that is similar to vitamin D. Vitamin D helps your body absorb calcium. Taking calcium supplements along with calcipotriene might cause the body to have too much calcium.

• Digoxin interacts with CALCIUM

Calcium can affect your heart. Digoxin is used to help your heart beat stronger. Taking calcium along with digoxin might increase the effects of digoxin and lead to an irregular heartbeat

• Diltiazem interacts with CALCIUM

Calcium can affect your heart. Diltiazem can also affect your heart. Taking large amounts of calcium along with diltiazem might decrease the effectiveness of diltiazem.

• Levothyroxine interacts with CALCIUM

Calcium can decrease how much levothyroxine your body absorbs. Taking calcium along with levothyroxine might decrease the effectiveness of levothyroxine. Levothyroxine and calcium should be taken at least 4 hours apart.

• LITHIUM interacts with CALCIUM 

• Sotalol interacts with CALCIUM

Taking calcium along with sotalol might decrease the effectiveness of sotalol. To avoid this interaction, take calcium at least 2 hours before or 4 hours after taking sotalol.

• Verapamil interacts with CALCIUM

Calcium can affect your heart. Verapamil (Calan, Covera, Isoptin, Verelan) can also affect your heart. Do not take large amounts of calcium if you are taking verapamil.

• Water pills (Thiazide diuretics) interacts with CALCIUM

Some “water pills” increase the amount of calcium in your body. Taking large amounts of calcium with some “water pills” might cause there to be too much calcium in the body. This could cause serious side effects, including kidney problems. Some of these “water pills” include chlorothiazide, hydrochlorothiazide, indapamide, metolazone, and chlorthalidone.

Minor Interaction: These combinations should be avoided or used watchfully. 

• Estrogens interacts with CALCIUM

Estrogen helps your body absorb calcium. Taking estrogen pills along with large amounts of calcium might increase calcium in the body too much. Estrogen pills include conjugated equine estrogens, ethinyl estradiol, estradiol, and others.

• Medications for high blood pressure (Calcium channel blockers) interacts with CALCIUM
  Some medications for high blood pressure affect calcium in your body. These medications are called calcium channel blockers. Getting calcium injections might decrease the effectiveness of these medications for high blood pressure. Some medications for high blood pressure include nifedipine, verapamil, diltiazem, isradipine, felodipine, amlodipine, and others.

OVERDOSAGE

Individuals 19 or older, should not take more than 2,500mg of calcium each day, and individuals 18 or younger, should not go over 3,000 mg daily.

Ingesting too much calcium can cause Constipation, Kidney stones, possibly trouble absorbing other minerals, such as iron and zinc, Irregular heartbeats.

One should take note of Recommended Dietary Allowances when taking a Calcium supplement, otherwise, health issues may occur as mentioned above.

CONTRAINDICATIONS

Calcium tablets (Calciboon ZM) are contraindicated in the following conditions:

• Allergy to Calcium Citrate
• Sarcoidosis
• Increased activity of the parathyroid gland
• A high amount of calcium in urine
• The high amount of calcium in the blood
• Dehydration
• Constipation
• Kidney stones
• Decreased kidney function
• The high amount of phosphate in the blood
• An excessive amount of vitamin D in the body
• A blockage of the arteries called arteriosclerosis obliterans

Store in a cool and dry place, protected from light.

Strip of 30 tablets.