Each film-coated tablet contains (Approx)

Curcumin …………………. 500mg

(Curcuminoids 95%)

Moringa……………………. 500mg

Lycopene (6%)………… 2000mcg

Piperine………………………. 5mg

Excipients……………………. Q.S.

Curcumin^1,2

• Established as powerful anti-oxidant with anticancer properties

Moringa³

• Highly nutritious profile : 4 times the Vitamin A of carrots, 7 times the Vitamin C of oranges,4 times the Calcium of milk, 3 times the Potassium of bananas, ¾ the iron of Spinach, and 2 times the Protein of yogurt

Lycopene⁴

• Well known powerful antioxidant

Piperine⁵

• Enhanced bioavailability with addition of Piperine

Curcumin is present as curcuminoids, the biological active components in turmeric. Comprehensive research over the last century has revealed several important functions of curcuminoids. Various preclinical cell culture and animals studies suggest that curcuminoids have extensive biological activity as an antioxidant, neuroprotective, antitumor, anti-inflammatory, anti-acidogenic, radioprotective and arthritis (anti-arthritic). The array of biological activities suggests a potential role for curcuminoids in cancer patients as a preventive and / or therapeutic agent. 

Pharmacokinetics⁷

Efficient first-pass metabolism and some degree of intestinal metabolism, particularly glucuronidation and sulfation of curcumin, might explain its poor systemic availability when administered via the oral route. Piperine is known to enhance bioavailability of Curcumin by 2000%. A daily oral dose of 3.6 g of curcumin is compatible with detectable levels of the parent compound in colorectal tissue from patients with cancer. The levels demonstrated might be sufficient to exert pharmacological activity. There appears to be negligible distribution of the parent drug to hepatic tissue or other tissues beyond the gastrointestinal tract.

Curcumin supplement is most commonly useful in:

• Patients undergoing Radiation & Chemotherapy
• TB patients
• Asthmatics
• Patients recovering from Cancer
• Adults for healthy living

One tablet twice a day or as directed by the Dietitian.

Large amounts of Curcumin, more than the recommended doses, may cause severe stomach upset and irritation. Because of its blood-thinning effect, Curcumin may stimulate contractions in pregnant women. Hence, caution is needed.

• Blood-thinning medications:Curcumin supplement may make the effects of these drugs stronger, raising the risk of bleeding. Blood-thinners include warfarin, clopidogrel, and aspirin, among others.
• Drugs that reduce stomach acid:Curcumin supplement may interfere with the action of these drugs, increasing the production of stomach acid: Cimetidine, Famotidine, Ranitidine, Esomeprazole, Omeprazole and Lansoprazole
• Drugs for diabetes (that lower blood sugar):Curcumin supplement may make the effects of these drugs stronger, increasing the risk of hypoglycemia (low blood sugar).

Caution should be used while using these drugs with Curcumin supplement.

CONTRAINDICATIONS

Curcumin supplements are contraindicated in patients suffering from gallstones or bile duct obstruction and bleeding disorders

Store in a cool and dry place below 25^o C.

Box containing 3 strips of 10 tablets each.

1. Pharmaceutical aspects of Curcumin: Review Article. Alsamydai and Jaber, IJP, 2018; Vol.5(6):313-326.
2. Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice. Cancer Res Treat.2014;46(1):2-18.
3. Adoption of Moringa oleiferato combat under-nutrition viewed through the lens of the “Diffusion of Innovations” theory. Ecol Food Nutr 2009 May 1;48(3):212-225.
4. Lycopene: a review of its potential as an anticancer agent. Curr Med Chem Anticancer Agents. 2005 Nov;5(6):627-35.
5. Curcumin: A Review of Its’ Effects on Human Health. Foods. 2017 Oct; 6(10): 92.
6. Journal of Traditional and Complementary Medicine. Vol 7, Issue 2, April 2017, Pages 205-223.
7. Pharmacokinetics and pharmacodynamics of curcumin. Adv Exp Med Biol.2007;595:453-70.
8. http://pennstatehershey.adam.com/content.aspx?productId=107&pid=33&gid=000932 (Accessed on 26^th March 2019).
9. https://www.medicalnewstoday.com/articles/318405.php (Accessed on 26^th March 2019).
10. https://1md.org/article/turmeric-gallbladder-health-gallstones (Accessed on 26^th March 2019).