Pack Size: 1 vial
Drug Class: Cytostatics
Dosage and Administration:
70 mg/m2 PO once daily on days 1 to 4 in combination with other approved chemotherapeutic agents, every 3 to 4 weeks. Alternatively, administer etoposide 100 mg/m2 PO once daily on days 1 to 5 in combination with other approved chemotherapeutic agents, every 3 to 4 weeks.
Cold Storage: no
Zuvitop-100 (etoposide Injection, IP) is a semisynthetic derivative of podophyllotoxin used in the treatment of certain neoplastic diseases. It is 4′-demethylepipodophyllotoxin 9-[4,6-0-(R)- ethylidence – B-D- glucopyranoside]. It is very soluble in methanol and chloroform, slightly soluble in ethanol, and sparingly soluble in water and ether. It is made more miscible with water by means of organic solvents. It has a molecular weight of 588.58 and a molecular formula of C29 H32 O13.
The Structural formula is :
- Etoposide Injection is indicated in the management of the following neoplasms.
- Small cell lung cancer, malignant lymphomas
- Acute leukemia’s… Testicular tumors.
- Bladder Cancer. Trophoblastic diseases
- Etoposide Injection are indicated in the management of the following neoplasms.
- Small cell lung cancer. Malignant lymphomas.
Etoposide phosphate is a prodrug that is converted to its active moiety, etoposide, by dephosphorylation. Etoposide causes the induction of DNA strand breaks by an interaction with DNAtopoisomerase II or the formation of free radicals, leading to cell cycle arrest, primarily at the G2 stage of the cell cycle, and cell death.
Etoposide is a cytotoxic anticancer drug used for the treatment of testicular and small cell lung cancers. Exposure to Etoposide may cause adverse effects to the digestive system, irritation, or allergic reaction and may affect the blood forming system and respiratory system.
Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.
Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters